منابع مشابه
Mechanisms of Cisplatin Nephrotoxicity
Cisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years has uncovered many of the cellular mechanisms which underlie cisplatin-induced renal cell death. It has also become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney inju...
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Each of the major classes of clinically useful antibiotics can cause neph rotoxicity. Major differences exist among classes, and these are reviewed with regard to the frequency of occurrence of nephrotoxicity, the direct or indirect toxic effects of the drugs, their site(s) of action within the kidney, current views of their pathophysiological effects and observations which provide clues to th...
متن کاملAcute Nephrotoxicity of Cisplatin: Molecular mechanisms Authors
Nephrotoxic drugs are responsible for approximately 20% of the episodes of acute kidney injury (AKI) in hospital and outpatient settings. Among elderly individuals, the incidence of drug-induced nephrotoxicity can be as high as 66%. Cisplatin (cis-diamminedichloroplatinum II CDDP) is an oncologic medication included in most chemotherapy regimens for solid or hematologic tumors. Cisplatin’s anti...
متن کاملCellular and molecular mechanisms of cyclosporin nephrotoxicity.
Cyclosporin therapy is associated with several forms of nephrotoxicity, the most significant of which are reversible impairment of glomerular filtration and irreversible interstitial fibrosis. Impaired glomerular filtration is due to both reduction in Kf, the glomerular capillary ultrafiltration coefficient, and to reduction in renal blood flow. The mechanisms responsible for the low Kf are not...
متن کاملCisplatin nephrotoxicity: mechanisms and renoprotective strategies.
Cisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the use of cisplatin and related platinum-based therapeutics. Recent research has shed significant new lights on the mechanism of cisplatin nephrotoxicity, especially on the signaling pathways leading to tubular cell death ...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1983
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.8.1